Studying oncogenic signatures in cancers
Cancer is a disease in which abnormal cells acquire the ability to divide without control and invade other tissues. These attributes arise due to genetic and epigenetic alterations that disrupt molecular pathways regulating genomic stability, cell proliferation, and cell death. Since, cancer data analysis involves large numbers of variables, high dimensional clustering methods are required [...]
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Analysis of tumour genomic markers to define pathway deviations
Genomic analysis of cancer will lead to better understanding of cancer biology and help to generate tumour and circulatory molecular markers, that aid early diagnosis and improve the management of the cancer. The main objective of the project is the meta-analysis of published metastatic prostate cancer data sets to generate changes seen to further define [...]
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Studying coevolution of Dengue virus and Host
The number of cases and severity of disease associated with Dengue infection in Sri Lanka has been increasing since 1989. Studies shows that prior to 2009 DENV2 and DENV3 serotypes are dominant and DENV3 caused the epidemics in the years of 2002 and 2004. In 2009 DENV1 was the major disease causing serotype in Sri [...]
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